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  • Nano One Selected to Join U.S. ALTA and Strengthen North American Battery Supply Chain

    Nano One Selected to Join U.S. ALTA and Strengthen North American Battery Supply Chain

    Highlights

    • Nano One selected for launch of ALTA, America’s first lithium and battery supply chain accelerator.

    • Only OBBB-ready solution for LFP-linking upstream critical minerals to downstream cell manufacturing.

    • Eliminates chokepoints and reliance on foreign-controlled processes, inputs and wasteful ecosystems.

    • Nano One begins trading on US listing (OTCQB: NNOMF) to enhance investor base.

    VANCOUVER, BRITISH COLUMBIA / ACCESS Newswire / July 15, 2025 / (TSX:NANO)(OTC PINK:NNOMF)(Frankfurt:LBMB)

    Nano One® Materials Corp. (“Nano One” or the “Company”), a process technology company specializing in lithium-ion battery cathode active materials (CAM), has been selected to join the Arkansas Lithium Technology Accelerator (ALTA), America’s first lithium and battery supply chain accelerator, to help catalyze a durable, domestic battery materials ecosystem and reduce foreign dependency on critical technology and inputs.

    Participating in ALTA positions Nano One as a strategic contributor to lithium-ion battery supply chain independence,” said Dan Blondal, CEO of Nano One. “We are the only OBBB-ready solution for LFP-linking upstream mineral extraction to downstream cell manufacturing. Without localized cathode production in the supply chain, critical minerals risk being sent offshore for processing or worse yet, idled while U.S. battery plants source elsewhere. Our One-Pot™ process eliminates chokepoints and reliance on foreign-controlled inputs, processing technologies, wastewater and byproducts that will not scale here. Purpose-built for North America, it vertically integrates PCAM with CAM-cutting costs, reducing permitting barriers, and unlocking a scalable, modular platform at the core of the lithium-ion battery ecosystem.”

    Simplified Lithium-ion battery supply chain

    Image: Simplified Lithium-ion battery supply chain.

    This milestone reinforces Nano One’s position as a national strategic asset in lithium-ion battery production- fortifying a secure, localized supply chain for defense and commercial markets. It also highlights Nano One’s continued relevance to energy growth and national security, bolstered by recent funding of US$12.9 million from the U.S. Department of Defense. Nano One’s Candiac facility, in Québec, is scaling operations towards initial sales for defense and energy storage, while supporting licensing and joint venture efforts to address high-volume markets for AI data centers and electric vehicles. Arkansas’ bold yet achievable supply chain goals align with Nano One’s multi-jurisdictional strategy, leveraging Candiac as a hub, accelerator and launchpad for validation, commercialization, and large-scale growth in the US, Canada and beyond. These efforts are anchored by Nano One’s Innovation Centre in Burnaby, which supports process development, scale-up, regional deployment, and long-term competitiveness.

    We’re thrilled to have Nano One join the ALTA program. Their One-Pot LFP technology represents the kind of breakthrough innovation that supports the national goal of reshoring supply chains. It’s a strong fit for Arkansas’ rapidly growing lithium ecosystem,” said Arthur Orduña, executive director of The Venture Center. Nano One is one of only three companies selected for ALTA’s inaugural cohort, alongside innovators in lithium processing and geothermal deployment. The accelerator is backed by Standard Lithium, the Walton Family Foundation, and a network of Arkansas-based producers, academic institutions, and government partners. Participation in ALTA creates opportunities for partnerships and strategic visibility in the U.S., while enabling shared learnings with other innovative North American supply chain leaders of tomorrow and established players looking to support localization of the lithium-ion battery supply chain.

    To capitalize on this momentum, Nano One began trading on the U.S. OTCQB under the ticker NNOMF on July 14, enhancing visibility and accessibility to U.S. investors as it expands commercial efforts and builds partnerships across North America. Momentum is further supported by policy shifts like the One Big Beautiful Bill (OBBB), which proposes tighter domestic content requirements and phases out incentives tied to foreign inputs. With CAM representing the highest cost component in a cell, Nano One’s One-Pot™ process provides a path to resilient, cost competitive, and fully domestic manufacturing.

    ###

    About Nano One®
    Nano One® Materials Corp. (Nano One) is a technology company changing how the world makes cathode active materials for lithium-ion batteries. Applications include stationary energy storage systems (ESS), portable electronics, and electric vehicles (EVs). The Company’s patented One-Pot process reduces costs, is easier-to permit, lowers energy intensity, environmental footprint, and reliance on problematic supply chains. The Company is helping to drive energy security, supply chain resilience, industrial competitiveness and increased performance through process innovation. Scalability is proven and being demonstrated at Nano One’s LFP (lithium-iron-phosphate) pilot production plant in Québec-leveraging the only facility and expertise of its kind outside of Asia. Strategic collaborations and partnerships with international companies like Sumitomo Metal Mining, Rio Tinto, and Worley are supporting a design-one-build-many licensing growth strategy-delivering cost-competitive, easier-to-permit and faster-to-market battery materials production solutions world-wide. Nano One has received funding from the Government of Canada, the Government of the United States, the Government of Québec, and the Government of British Columbia. For more information, please visit www.nanoone.ca.

    Company Contact
    Paul Guedes
    info@nanoone.ca
    +1 (604) 420-2041

    Cautionary Notes and Forward-Looking Statements

    Certain information contained herein may constitute “forward-looking information” and “forward-looking statements” within the meaning of applicable securities legislation. All statements, other than statements of historical fact, are forward-looking statements. Forward-looking information includes but is not limited to: LFP production, joint ventures, contracted projects, revenue generation, operational growth, licensing, government funding, the development of technology, supply chains, and plans for construction and operation of cathode production facilities; the Company’s current and future business and strategies; estimated future working capital, funds available, and uses of funds, future capital expenditures and other expenses for commercial operations; industry demand; incurrence of costs; competitive conditions; general economic conditions; the intention to grow the business, operations and potential activities of the Company; the functions and intended benefits of Nano One’s technology and product the development and optimization of the Company’s technology and products; prospective partnerships and the anticipated benefits of the Company’s partnerships; the ability to attract and retain key talent; the Company’s licensing and, the scalability of developed technology to meet expanded capacity; and the execution of the Company’s stated plans – which are contingent on access to capital and grants.

    Generally, forward-looking information can be identified by the use of terminology such as ‘believe’, ‘expect’, ‘anticipate’, ‘plan’, ‘intend’, ‘continue’, ‘estimate’, ‘may’, ‘will’, ‘should’, ‘ongoing’, ‘target’, ‘goal’, ‘potential’ or variations of such words and phrases or statements that certain actions, events or results “will” occur.

    Forward-looking statements are based on the current opinions and estimates of management as of the date such statements are made are not, and cannot be, a guarantee of future results or events. Forward-looking statements are subject to known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of the Company to be materially different from those expressed or implied by such forward-looking statements or forward-looking information, including but not limited to: general and global economic and regulatory changes; next steps and timely execution of the Company’s business plans; the development of technology, supply chains, and plans for construction and operation of cathode production facilities; successful current or future collaborations that may happen with OEM’s, miners or others; the execution of the Company’s plans which are contingent on capital sources; the Company’s ability to achieve its stated goals; the commercialization of the Company’s technology and patents via license, joint venture and independent production; anticipated global demand and projected growth for LFP batteries; and other risk factors as identified in Nano One’s MD&A and its Annual Information Form dated March 25, 2025, both for the year ended December 31, 2024, and in recent securities filings for the Company which are available at www.sedarplus.ca. Although management of the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements or forward-looking information, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements and forward-looking information. The Company does not undertake any obligation to update any forward-looking statements or forward-looking information that is incorporated by reference herein, except as required by applicable securities laws. Investors should not place undue reliance on forward-looking statements.

    SOURCE: Nano One Materials Corp.

    View the original press release on ACCESS Newswire

  • Patton Myhre Launches New Website Showcasing Integrated Valve & Automation Solutions

    Patton Myhre Launches New Website Showcasing Integrated Valve & Automation Solutions

    Houston, TX – Patton Myhre Sourcing, LP, a premier midstream valve and actuation supplier serving the oil and gas industry throughout North America for over 20 years, is excited to announce the launch of a newly designed website. The new website reflects Patton Myhre’s commitment to operational excellence, integrated manufacturing capabilities, and comprehensive field services, offering an enhanced online experience that meets the evolving needs of midstream energy companies seeking reliable valve solutions.

    Patton Myhre Sourcing, LP has established itself as a trusted leader in the midstream oil and gas market, founded by partners Daniel Patton and Bruce Myhre who bring over 50 years of combined experience in procurement, manufacturing, and sales. Operating from their fully integrated 15002 Boudreaux Road facility in Tomball, Texas, the company specializes in supplying a comprehensive range of API 6D valves including ball valves, gate valves, check valves, plug valves, butterfly valves, and control valves, along with complete valve automation solutions. With their “under one roof” approach to value-added services and strategic partnerships with reputable manufacturers, Patton Myhre has built a reputation for delivering quality products with shorter lead times and exceptional customer service. As the company continues to expand its reach across North America while maintaining its commitment to in-house manufacturing excellence, it recognized the need for a modern, professional website that accurately represents its integrated capabilities and industry expertise. To achieve this, Patton Myhre partnered with ASTOUNDZ, an internet marketing firm renowned for its expertise in creating optimized, high-performance websites that deliver results.

    “Our goal was to create a website that not only looks professional but also functions seamlessly across all devices,” said Steve Winter, founder of ASTOUNDZ. “We wanted to ensure that Patton Myhre’s clients have easy access to the information they need, whether they’re seeking valve specifications, automation solutions, or comprehensive field services.”

    The new Patton Myhre website features a sleek, modern design that emphasizes the company’s integrated manufacturing approach and comprehensive service capabilities. ASTOUNDZ applied its “ONE SEARCH, ONE CLICK, ONE COMPANY” philosophy to the design process, ensuring that energy industry professionals can find what they need quickly and efficiently. The site’s navigation is intuitive, with clearly defined sections for Patton Myhre’s key service areas, including midstream valve supply, custom valve modifications, automation solutions, field services, and their extensive manufacturer partnerships.

    “Patton Myhre is all about being your energy products partner, and our website needed to reflect that mission,” Daniel Patton. “ASTOUNDZ helped us create a digital presence that not only looks professional but also makes it easier for our clients to understand our integrated capabilities and access our comprehensive valve and automation solutions.”

    Beyond aesthetics, the new Patton Myhre website is fully optimized for search engines, ensuring that midstream energy companies can easily find the company online when searching for valve and automation solutions. ASTOUNDZ’s expertise as an organic SEO company played a crucial role in this aspect of the project. The website is designed to rank highly on search engines like Google, Bing, and Yahoo, driving more traffic and generating more leads for Patton Myhre’s specialized services.

    “SEO is a critical component of any modern website,” Winter explained. “We made sure that Patton Myhre’s site is not only visually appealing but also performs well in search results, helping them reach more energy companies throughout North America and grow their valve supply business.”

    One of the standout features of the new website is its mobile responsiveness. With more energy industry professionals accessing the internet via smartphones and tablets while working in the field, it was essential that the Patton Myhre site provides a seamless experience across all devices. ASTOUNDZ ensured that the website is fully responsive, meaning it adapts perfectly to any screen size, from desktops to mobile phones.

    “A great user experience is about more than just design,” said Patton. “It’s about making sure that our clients can access our services wherever they are, on whatever device they’re using. The new website does exactly that, whether someone needs emergency valve replacement or wants to explore our comprehensive automation capabilities.”

    As Patton Myhre continues to expand its services and serve new markets throughout North America, the new website provides a strong foundation for future growth. The site’s backend is built to support ongoing updates and additions, allowing Patton Myhre to keep its content fresh and relevant. This flexibility ensures that the website will continue to serve the company’s needs as it grows and evolves in the competitive energy supply industry.

    About Patton Myhre Sourcing, LP

    Patton Myhre Sourcing, LP is a 100% a veteran owned business premier midstream valve and actuation supplier serving the oil and gas industry throughout North America. Founded by partners Daniel Patton and Bruce Myhre, who bring over 50 years of combined experience in procurement, manufacturing, and sales, the company has been serving the midstream energy market for over 20 years from their fully integrated facility in Tomball, Texas. Patton Myhre specializes in supplying API 6D valves including ball valves, gate valves, check valves, plug valves, butterfly valves, and control valves, along with comprehensive automation solutions and field services. Their “under one roof” approach ensures total control over product quality through in-house machining, assembly, and quality assurance processes, while their strategic partnerships with reputable manufacturers enable them to provide high-quality, reliable products for midstream applications. The company operates a fully equipped field service fleet and offers comprehensive value-added services including installation, commissioning, troubleshooting, and preventative maintenance programs.

    About ASTOUNDZ

    ASTOUNDZ is a Houston-based digital marketing and web development company specializing in creating optimized, high-performance websites that deliver measurable results. With a commitment to excellence and customer satisfaction, ASTOUNDZ offers a full range of digital marketing services, including SEO, web design, social media marketing, and more.

  • Fresh Online Experience Highlights Cornerstone’s $278M+ Sales Impact Across B2B Sectors

    Fresh Online Experience Highlights Cornerstone’s $278M+ Sales Impact Across B2B Sectors

    Cornerstone Growth Solutions, a premier B2B sales outsourcing company that has helped over 378 companies grow their sales by more than $278 million, has launched a newly designed website showcasing its commitment to guaranteed results and proven sales processes. Developed in partnership with ASTOUNDZ, the new site delivers an enhanced digital experience for technology and professional services companies seeking predictable, scalable revenue growth.

    Cornerstone Growth Solutions has established itself as a trusted leader in B2B sales outsourcing, founded by Charles Alvarez and led by Chief Sales Officer Kurt Lienhard. Specializing in helping technology companies, technology services companies, and professional services companies acquire new clients, the company offers comprehensive solutions including lead generation, appointment setting, relationship development, and sales closing services. With their unique “Unmatched Performance Guarantee” and proven 7-step business-to-business sales process, Cornerstone Growth Solutions has demonstrated consistent success in driving revenue growth for clients across diverse industries. As the company continues to expand its client base and maintain its reputation for delivering results, it recognized the need for a modern, professional website that accurately represents its performance-driven approach and guaranteed outcomes methodology. To achieve this, Cornerstone Growth Solutions partnered with ASTOUNDZ, an internet marketing firm renowned for its expertise in creating optimized, high-performance websites that deliver results.

    “Our goal was to create a website that not only looks professional but also functions seamlessly across all devices,” said Steve Winter, founder of ASTOUNDZ. “We wanted to ensure that Cornerstone Growth Solutions’ clients have easy access to the information they need, whether they’re seeking lead generation services, appointment setting, or comprehensive sales outsourcing solutions.”

    The new Cornerstone Growth Solutions website features a sleek, modern design that emphasizes the company’s performance guarantee and proven methodologies. ASTOUNDZ applied its “ONE SEARCH, ONE CLICK, ONE COMPANY” philosophy to the design process, ensuring that potential clients can find what they need quickly and efficiently. The site’s navigation is intuitive, with clearly defined sections for Cornerstone Growth Solutions’ key service areas, including lead generation, qualified appointment setting, AI-driven targeting, relationship building, and comprehensive sales closing services.

    “Cornerstone Growth Solutions is all about generating sales, not excuses, and our website needed to reflect that mission,” said Charles Alvarez, CEO and founder of Cornerstone Growth Solutions. “ASTOUNDZ helped us create a digital presence that not only looks professional but also makes it easier for our clients to understand our guaranteed approach and see how we can help them achieve their revenue objectives.”

    Beyond aesthetics, the new Cornerstone Growth Solutions website is fully optimized for search engines, ensuring that companies seeking B2B sales outsourcing services can easily find the company online. ASTOUNDZ’s expertise as an organic SEO company played a crucial role in this aspect of the project. The website is designed to rank highly on search engines like Google, Bing, and Yahoo, driving more traffic and generating more leads for Cornerstone Growth Solutions’ specialized services.

    “SEO is a critical component of any modern website,” Winter explained. “We made sure that Cornerstone Growth Solutions’ site is not only visually appealing but also performs well in search results, helping them reach more technology and professional services companies looking for guaranteed sales growth solutions.”

    One of the standout features of the new website is its mobile responsiveness. With more business decision-makers accessing the internet via smartphones and tablets, it was essential that the Cornerstone Growth Solutions site provides a seamless experience across all devices. ASTOUNDZ ensured that the website is fully responsive, meaning it adapts perfectly to any screen size, from desktops to mobile phones.

    “A great user experience is about more than just design,” said Alvarez. “It’s about making sure that our clients can access our services wherever they are, on whatever device they’re using. The new website does exactly that, whether someone needs immediate lead generation support or wants to learn about our comprehensive sales outsourcing programs.”

    As Cornerstone Growth Solutions continues to expand its services and serve new markets, the new website provides a strong foundation for future growth. The site’s backend is built to support ongoing updates and additions, allowing Cornerstone Growth Solutions to keep its content fresh and relevant. This flexibility ensures that the website will continue to serve the company’s needs as it grows and evolves in the competitive B2B sales outsourcing industry.

    About Cornerstone Growth Solutions

    Cornerstone Growth Solutions is a premier B2B sales outsourcing company that specializes in helping technology companies, technology services companies, and professional services companies acquire new clients. Founded by Charles Alvarez and led by Chief Sales Officer Kurt Lienhard, the company has helped over 378 companies grow their sales by more than $278 million through comprehensive lead generation, appointment setting, relationship development, and sales closing services. Cornerstone Growth Solutions offers an “Unmatched Performance Guarantee” – if they don’t hit your sales objective within your desired timeframe, they will continue working at no cost until they deliver results. The company leverages a proven 7-step business-to-business sales process, AI-driven targeting, LinkedIn outreach, and multi-channel engagement strategies to connect clients with qualified prospects who have the budget, need, and timeframe to make purchasing decisions.

    About ASTOUNDZ

    ASTOUNDZ is a Houston-based digital marketing and web development company specializing in creating optimized, high-performance websites that deliver measurable results. With a commitment to excellence and customer satisfaction, ASTOUNDZ offers a full range of digital marketing services, including SEO, web design, social media marketing, and more.

  • Veteran-Owned Freedom K9 Launches New Website to Expand Reach Across Houston

    Veteran-Owned Freedom K9 Launches New Website to Expand Reach Across Houston

    Houston, Texas – Freedom K9, a premier veteran-owned dog training company serving the Greater Houston area, has launched a newly designed website that reflects its commitment to professional excellence, military precision, and transformative canine training. Built in partnership with ASTOUNDZ, the new site offers an enhanced online experience tailored to the needs of dog owners seeking expert behavioral solutions.

    Freedom K9 has established itself as Houston’s trusted leader in professional dog training, founded by Darryl Richey, a U.S. Army veteran with the 82nd Airborne Division and PSA Hall of Fame inductee with over 26 years of dog training expertise. Serving the entire Greater Houston region from their Tomball, Texas location, the company specializes in comprehensive training programs including Board and Train services, advanced off-leash training, behavioral modification, and personal protection dog training. As Freedom K9 continues to expand its reach and maintain its reputation for transformative results, it recognized the need for a modern, professional website that accurately represents its military-grade training excellence and veteran-owned values. To achieve this, Freedom K9 partnered with ASTOUNDZ, an internet marketing firm renowned for its expertise in creating optimized, high-performance websites that deliver results.

    “Our goal was to create a website that not only looks professional but also functions seamlessly across all devices,” said Steve Winter, founder of ASTOUNDZ. “We wanted to ensure that Freedom K9’s clients have easy access to the information they need, whether they’re seeking Board and Train programs, behavioral modification services, or free training evaluations.”

    The new Freedom K9 website features a sleek, modern design that emphasizes the company’s military precision and professional expertise. ASTOUNDZ applied its “ONE SEARCH, ONE CLICK, ONE COMPANY” philosophy to the design process, ensuring that dog owners can find what they need quickly and efficiently. The site’s navigation is intuitive, with clearly defined sections for Freedom K9’s key service areas, including Board and Train programs, advanced off-leash training, puppy training, behavioral modification, and personal protection services.

    “Freedom K9 is all about giving dogs and their owners the freedom they’ve never imagined, and our website needed to reflect that mission,” said Darryl Richey, founder of Freedom K9. “ASTOUNDZ helped us create a digital presence that not only looks professional but also makes it easier for our clients to understand our unique training approach and schedule their free evaluations.”

    Beyond aesthetics, the new website is fully optimized for search engines, ensuring that dog owners throughout Houston can easily find the company online. ASTOUNDZ’s expertise as an organic SEO company played a crucial role in this aspect of the project. The website is designed to rank highly on search engines like Google, Bing, and Yahoo, driving more traffic and generating more leads for Freedom K9’s specialized training programs.

    “SEO is a critical component of any modern website,” Winter explained. “We made sure that Freedom K9’s site is not only visually appealing but also performs well in search results, helping them reach more dog owners throughout Greater Houston and grow their veteran-owned business.”

    One of the standout features of the new website is its mobile responsiveness. With more dog owners accessing the internet via smartphones and tablets, it was essential that the Freedom K9 site provides a seamless experience across all devices. ASTOUNDZ ensured that the website is fully responsive, meaning it adapts perfectly to any screen size, from desktops to mobile phones.

    “A great user experience is about more than just design,” said Richey. “It’s about making sure that our clients can access our training services wherever they are, on whatever device they’re using. The new website does exactly that, whether someone needs emergency behavioral modification or wants to learn about our advanced off-leash training programs.”

    As Freedom K9 continues to expand its services and serve new communities throughout the Houston area, the new website provides a strong foundation for future growth. The site’s backend is built to support ongoing updates and additions, allowing Freedom K9 to keep its content fresh and relevant. This flexibility ensures that the website will continue to serve the company’s needs as it grows and evolves in the competitive dog training industry.

    About Freedom K9

    Freedom K9 is a veteran-owned professional dog training company serving the Greater Houston area from Spring, Texas. Founded by Darryl Richey, a U.S. Army veteran with the 82nd Airborne Division and PSA Hall of Fame inductee with over 26 years of expertise, Freedom K9 specializes in Board and Train programs, advanced off-leash training, behavioral modification, personal protection dog training, and service dog preparation. The company serves Spring, Conroe, Magnolia, The Woodlands, Katy, Houston, Cypress, Humble, and surrounding areas, providing comprehensive training solutions that give dogs and their owners more freedom than they’ve ever imagined.

    About ASTOUNDZ

    ASTOUNDZ is a Houston-based digital marketing and web development company specializing in creating optimized, high-performance websites that deliver measurable results. With a commitment to excellence and customer satisfaction, ASTOUNDZ offers a full range of digital marketing services, including SEO, web design, social media marketing, and more.

  • New Website Launch Showcases The Ambrose Group’s Relationship-Driven Real Estate Expertise

    New Website Launch Showcases The Ambrose Group’s Relationship-Driven Real Estate Expertise

    The Ambrose Group, a trusted real estate consulting firm with over 30 years of service across Texas, has launched a newly designed website that reflects its commitment to relationship-driven service and expert financial consulting. Created in partnership with ASTOUNDZ, the new site offers an enhanced digital experience for property owners, investors, and professionals seeking comprehensive real estate solutions.

    The Ambrose Group has established itself as a trusted leader in the Texas real estate industry since 1994, founded and led by President David M. Ambrose, MAI, who brings over 30 years of experience in commercial real estate valuation and holds the prestigious MAI designation from the Appraisal Institute. Operating from multiple locations including Houston, Dallas and San Antonio, the company specializes in comprehensive real estate consulting services including property appraisals, property tax consulting, cost segregation studies, and commercial brokerage services. With a team of 44 professionals including certified appraisers, property tax consultants, construction engineers, and brokers, The Ambrose Group has built its reputation on their core philosophy: “Everything we do is driven by the relationship, not the transaction.” As the company continues to expand its service offerings while maintaining its commitment to personalized client relationships and expert financial solutions, it recognized the need for a modern, professional website that accurately represents its comprehensive capabilities and relationship-focused approach. To achieve this, The Ambrose Group partnered with ASTOUNDZ, an internet marketing firm renowned for its expertise in creating optimized, high-performance websites that deliver results.

    “Our goal was to create a website that not only looks professional but also functions seamlessly across all devices,” said Steve Winter, founder of ASTOUNDZ. “We wanted to ensure that The Ambrose Group’s clients have easy access to the information they need, whether they’re seeking property appraisals, tax consulting services, or cost segregation studies.”

    The new Ambrose Group website features a sleek, modern design that emphasizes the company’s relationship-driven philosophy and comprehensive service expertise. ASTOUNDZ applied its “ONE SEARCH, ONE CLICK, ONE COMPANY” philosophy to the design process, ensuring that property owners and investors can find what they need quickly and efficiently. The site’s navigation is intuitive, with clearly defined sections for The Ambrose Group’s key service areas, including commercial and residential appraisals, property tax consulting, cost segregation studies, real estate litigation support, and brokerage services.

    “The Ambrose Group is all about building sincere relationships that enhance our clients’ financial well-being, and our website needed to reflect that mission,” said David M. Ambrose, MAI, President of The Ambrose Group. “ASTOUNDZ helped us create a digital presence that not only looks professional but also makes it easier for our clients to understand our comprehensive services and access the expert guidance they need for their real estate investments.”

    Beyond aesthetics, the new Ambrose Group website is fully optimized for search engines, ensuring that property owners and investors throughout Texas can easily find the company online when searching for real estate consulting services. ASTOUNDZ’s expertise as an organic SEO company played a crucial role in this aspect of the project. The website is designed to rank highly on search engines like Google, Bing, and Yahoo, driving more traffic and generating more leads for The Ambrose Group’s specialized services.

    “SEO is a critical component of any modern website,” Winter explained. “We made sure that The Ambrose Group’s site is not only visually appealing but also performs well in search results, helping them reach more property owners and investors throughout Texas and grow their real estate consulting business.”

    One of the standout features of the new website is its mobile responsiveness. With more real estate professionals and property owners accessing the internet via smartphones and tablets, it was essential that The Ambrose Group site provides a seamless experience across all devices. ASTOUNDZ ensured that the website is fully responsive, meaning it adapts perfectly to any screen size, from desktops to mobile phones.

    “A great user experience is about more than just design,” said Ambrose. “It’s about making sure that our clients can access our services wherever they are, on whatever device they’re using. The new website does exactly that, whether someone needs property tax appeal support or wants to explore our cost segregation services for tax savings.”

    As The Ambrose Group continues to expand its services and serve new markets throughout Texas and beyond, the new website provides a strong foundation for future growth. The site’s backend is built to support ongoing updates and additions, allowing The Ambrose Group to keep its content fresh and relevant. This flexibility ensures that the website will continue to serve the company’s needs as it grows and evolves in the competitive real estate consulting industry.

    About The Ambrose Group

    The Ambrose Group is a premier real estate consulting firm serving Texas and beyond since 1994. Founded and led by President David M. Ambrose, MAI, who holds over 30 years of experience in commercial real estate valuation and the prestigious MAI designation from the Appraisal Institute, the company operates multiple offices in Houston, Dallas, and San Antonio. The Ambrose Group specializes in comprehensive real estate services including commercial and residential appraisals, property tax consulting, cost segregation studies, real estate litigation support, and commercial brokerage services. With a team of 44 professionals including certified appraisers, property tax consultants, construction engineers, and brokers, the company is built on core values of respect, integrity, commitment, enthusiasm, and teamwork. The Ambrose Group’s mission is guided by their philosophy: “Everything we do is driven by the relationship, not the transaction,” ensuring personalized service and long-term client partnerships that enhance financial well-being through expert real estate solutions.

    About ASTOUNDZ

    ASTOUNDZ is a Houston-based digital marketing and web development company specializing in creating optimized, high-performance websites that deliver measurable results. With a commitment to excellence and customer satisfaction, ASTOUNDZ offers a full range of digital marketing services, including SEO, web design, social media marketing, and more.

  • The Creature Teacher® Unveils New Website to Inspire Hands-On Wildlife Education Across Texas

    The Creature Teacher® Unveils New Website to Inspire Hands-On Wildlife Education Across Texas

    The Creature Teacher®, a premier wildlife education company serving Texas with hands-on animal programs for schools, libraries, and events, has launched a newly designed website that brings their mission of conservation and interactive learning to life. Created in collaboration with ASTOUNDZ, the site offers an enhanced experience for educators, families, and organizations seeking meaningful and memorable wildlife encounters.

    The Creature Teacher® has established itself as a trusted leader in wildlife education, bringing years of experience and a passion for connecting people with nature through interactive animal encounters. Operating across Texas with locations serving DFW, Houston, and Tyler/Longview areas, the company specializes in educational programs that align with TEKS standards while fostering curiosity and respect for wildlife. Their comprehensive offerings include school programs designed to support STAAR test preparation, birthday party entertainment, library programs, corporate events, scouting activities, and specialized presentations featuring exotic animals, conservation education, and innovative STEM activities including drone technology and water quality testing. With a team of expert educators holding advanced degrees in education and science, The Creature Teacher provides hands-on experiences with carefully selected animals including kangaroos, sloths, reptiles, mammals, amphibians, and birds, all maintained under USDA Class C Exhibitor licensing to ensure the highest standards of animal care and educational excellence. As the company continues to expand its franchise opportunities and serve new communities throughout Texas, it recognized the need for a modern, professional website that accurately represents its educational mission and comprehensive program offerings. To achieve this, The Creature Teacher partnered with ASTOUNDZ, an internet marketing firm renowned for its expertise in creating optimized, high-performance websites that deliver results.

    “Our goal was to create a website that not only looks professional but also functions seamlessly across all devices,” said Steve Winter, founder of ASTOUNDZ, “We wanted to ensure that The Creature Teacher’s clients have easy access to the information they need, whether they’re seeking school programs, birthday party entertainment, or educational resources for teachers.”

    The new Creature Teacher website features a sleek, modern design that emphasizes the company’s educational expertise and commitment to wildlife conservation. ASTOUNDZ applied its “ONE SEARCH, ONE CLICK, ONE COMPANY” philosophy to the design process, ensuring that educators, parents, and event organizers can find what they need quickly and efficiently. The site’s navigation is intuitive, with clearly defined sections for The Creature Teacher’s key service areas, including school programs, birthday parties, library presentations, corporate events, franchise opportunities, and their extensive collection of educational resources for teachers.

    “The Creature Teacher is all about bringing the wonder of wildlife to communities through interactive education programs that inspire and educate, and our website needed to reflect that mission,” said Henry from The Creature Teacher. “ASTOUNDZ helped us create a digital presence that not only looks professional but also makes it easier for our clients to understand our educational approach and book the perfect wildlife experience for their needs.”

    Beyond aesthetics, the new Creature Teacher website is fully optimized for search engines, ensuring that educators and families throughout Texas can easily find the company online when searching for wildlife education programs. ASTOUNDZ’s expertise as an organic SEO company played a crucial role in this aspect of the project. The website is designed to rank highly on search engines like Google, Bing, and Yahoo, driving more traffic and generating more leads for The Creature Teacher’s specialized educational services.

    “SEO is a critical component of any modern website,” Winter explained. “We made sure that The Creature Teacher’s site is not only visually appealing but also performs well in search results, helping them reach more educators and families seeking engaging wildlife programs and grow their educational business.”

    One of the standout features of the new website is its mobile responsiveness. With more educators and parents accessing the internet via smartphones and tablets, especially when planning educational activities or birthday parties, it was essential that The Creature Teacher site provides a seamless experience across all devices. ASTOUNDZ ensured that the website is fully responsive, meaning it adapts perfectly to any screen size, from desktops to mobile phones.

    “A great user experience is about more than just design,” said Belinda Henry. “It’s about making sure that our clients can access our services wherever they are, on whatever device they’re using. The new website does exactly that, whether someone needs to book a school program aligned with TEKS standards or wants to schedule an unforgettable birthday party with our kangaroo encounters.”

    As The Creature Teacher continues to expand its services and franchise opportunities throughout Texas and beyond, the new website provides a strong foundation for future growth. The site’s backend is built to support ongoing updates and additions, allowing The Creature Teacher to keep its content fresh and relevant. This flexibility ensures that the website will continue to serve the company’s needs as it grows and evolves in the competitive educational entertainment industry.

    About The Creature Teacher®

    The Creature Teacher® is a premier wildlife education company serving Texas and surrounding areas with interactive animal programs designed to inspire curiosity and foster respect for wildlife. Founded on the principle of making learning fun through hands-on experiences, the company operates across Texas with locations serving DFW, Houston, and Tyler/Longview areas, providing educational programs that align with TEKS standards and support STAAR test preparation. The Creature Teacher specializes in school programs, birthday party entertainment, library presentations, corporate events, scouting activities, and specialized conservation education featuring exotic animals including kangaroos, sloths, reptiles, mammals, amphibians, and birds. With a team of expert educators holding advanced degrees in education and science, the company maintains the highest standards through USDA Class C Exhibitor licensing, ensuring optimal animal care and educational excellence. The Creature Teacher’s innovative programs include traditional wildlife encounters as well as cutting-edge STEM activities featuring drone technology, water quality testing, and conservation presentations. The company also offers franchise opportunities for entrepreneurs passionate about wildlife education, providing comprehensive support including curriculum development, USDA licensing guidance, and ongoing coaching to help franchisees build successful educational businesses in their communities.

    About ASTOUNDZ

    ASTOUNDZ is a Houston-based digital marketing and web development company specializing in creating optimized, high-performance websites that deliver measurable results. With a commitment to excellence and customer satisfaction, ASTOUNDZ offers a full range of digital marketing services, including SEO, web design, social media marketing, and more.

  • Locke Protective Services Unveils New Website Showcasing 30+ Years of Trusted Security Excellence

    Locke Protective Services Unveils New Website Showcasing 30+ Years of Trusted Security Excellence

    Locke Protective Services, a premier commercial security company serving the greater Houston area for over 30 years, has launched a newly designed website that reflects its long-standing commitment to professional excellence, customer service, and trusted protection. Partnering with ASTOUNDZ, a leading digital marketing and web development company, Locke now offers an enhanced online experience tailored to the evolving needs of businesses seeking reliable security solutions.

    Locke Protective Services has established itself as Houston’s trusted provider of commercial security solutions since 1994, serving a diverse range of industries including office buildings, healthcare facilities, educational institutions, light and heavy industry, and residential neighborhoods. As the company continues to expand its capabilities and maintain its reputation for excellence, it recognized the need for a modern, professional website that accurately represents its three decades of security expertise. To achieve this, Locke Protective partnered with ASTOUNDZ, an internet marketing firm renowned for its expertise in creating optimized, high-performance websites that deliver results.

    Locke Protective

    “Our goal was to create a website that not only looks professional but also functions seamlessly across all devices,” said Steve Winter, founder of ASTOUNDZ. “We wanted to ensure that Locke Protective’s clients have easy access to the information they need, whether they’re seeking security assessments, guard services, or emergency response solutions.”

    The new Locke Protective website features a sleek, modern design that emphasizes security expertise and professional reliability. ASTOUNDZ applied its “ONE SEARCH, ONE CLICK, ONE COMPANY” philosophy to the design process, ensuring that potential clients can find what they need quickly and efficiently. The site’s navigation is intuitive, with clearly defined sections for Locke Protective’s key service areas, including commercial security guards, property protection, industry-specific solutions, and emergency response services.

    “Locke Protective is all about keeping Houston businesses safe and secure, and our website needed to reflect that mission,” said Bill Lakenmacher. “ASTOUNDZ helped us create a digital presence that not only looks professional but also makes it easier for our clients to connect with us and understand how we can protect their people, property, and assets.”

    Beyond aesthetics, the new Locke Protective website is fully optimized for search engines, ensuring that businesses seeking security services can easily find the company online. ASTOUNDZ’s expertise as an organic SEO company played a crucial role in this aspect of the project. The website is designed to rank highly on search engines like Google, Bing, and Yahoo, driving more traffic and generating more leads for Locke Protective.

    “SEO is a critical component of any modern website,” Winter explained. “We made sure that Locke Protective’s site is not only visually appealing but also performs well in search results, helping them reach more businesses and grow their security services throughout Houston.”

    One of the standout features of the new website is its mobile responsiveness. With more business owners and facility managers accessing the internet via smartphones and tablets, it was essential that the Locke Protective site provides a seamless experience across all devices. ASTOUNDZ ensured that the website is fully responsive, meaning it adapts perfectly to any screen size, from desktops to mobile phones.

    “A great user experience is about more than just design,” said Lakenmacher. “It’s about making sure that our clients can access our security services wherever they are, on whatever device they’re using. The new website does exactly that, whether someone needs immediate security consultation or wants to learn about our comprehensive protection services.”

    As Locke Protective continues to expand its services and serve new markets throughout the Houston area, the new website provides a strong foundation for future growth. The site’s backend is built to support ongoing updates and additions, allowing Locke Protective to keep its content fresh and relevant. This flexibility ensures that the website will continue to serve the company’s needs as it grows and evolves in the ever-changing security industry.

    About Locke Protective Services

    Locke Protective Services is a leading provider of commercial security solutions, serving businesses throughout Houston and surrounding areas since 1994. With over 30 years of trusted expertise, Locke Protective offers comprehensive security services including commercial security guards, property protection, and industry-specific security solutions for office buildings, healthcare facilities, educational institutions, and industrial properties. The company is dedicated to keeping Houston safe through proactive security measures, highly trained security professionals, and a commitment to exceptional customer service.

    About ASTOUNDZ

    ASTOUNDZ is a Houston-based digital marketing and web development company specializing in creating optimized, high-performance websites that deliver measurable results. With a commitment to excellence and customer satisfaction, ASTOUNDZ offers a full range of digital marketing services, including SEO, web design, social media marketing, and more.

  • Triton Thermal Launches New Website Showcasing Cutting-Edge Solutions for AI and High-Performance Computing

    Triton Thermal Launches New Website Showcasing Cutting-Edge Solutions for AI and High-Performance Computing

    A newly designed website for Triton Thermal, a cutting-edge liquid cooling solutions company specializing in advanced thermal management for data centers, high-performance computing, and AI applications, has been launched. The new website offers an intuitive, high-performance experience that reflects Triton Thermal’s commitment to engineering excellence, energy efficiency, and solving complex thermal challenges at scale. Built with IT leaders and data center operators in mind, the new site offers an enhanced online experience that meets the evolving needs of enterprises seeking to maximize computing performance while minimizing energy consumption.

    Triton Thermal has established itself as an innovative leader in the liquid cooling industry, engineering precision cooling solutions that address the unique thermal demands of modern computing environments. Specializing in direct liquid-to-chip cooling, rear-door heat exchangers, immersion cooling, and comprehensive cooling control systems, the company serves diverse markets including high-performance computing, AI systems, enterprise data centers, large-scale cloud providers, colocation facilities, and remote computing applications. Triton Thermal designs custom-tailored liquid cooling systems that reduce cooling energy costs by 30-50% and support high-density racks exceeding 100kW, making it a key partner for organizations tackling the thermal challenges of next-generation computing workloads. As the need for AI, high-performance computing, and cloud systems continues to surge, the company saw the importance of launching a modern website that reflects its advanced engineering capabilities and custom solution approach.

    Triton Thermal partnered with ASTOUNDZ, an internet marketing firm renowned for its expertise in creating optimized, high-performance websites, to create a final product that delivers on all fronts.

    “Our goal was to create a website that not only looks professional but also functions seamlessly across all devices,” said Steve Winter, founder of ASTOUNDZ. “We wanted to ensure that Triton Thermal’s clients have easy access to the information they need, whether they’re seeking direct liquid cooling solutions, immersion cooling systems, or comprehensive thermal management consulting.”

    The new Triton Thermal website features a sleek, modern design that emphasizes the company’s engineering expertise and custom solution capabilities. ASTOUNDZ applied its “ONE SEARCH, ONE CLICK, ONE COMPANY” philosophy to the design process, ensuring that data center professionals and IT decision-makers can find what they need quickly and efficiently. The site’s navigation is intuitive, with clearly defined sections for Triton Thermal’s key service areas, including direct liquid-to-chip cooling, rear door heat exchangers, immersion cooling, cooling control systems, and specialized solutions for colocation facilities.

    “Triton Thermal is all about engineering precision liquid cooling solutions that maximize performance across diverse computing environments, and our website needed to reflect that mission,” said Mike Donovan, Principal of Triton Thermal. “ASTOUNDZ helped us create a digital presence that not only looks professional but also makes it easier for our clients to understand our custom approach to thermal management and access the advanced cooling solutions they need to stay competitive.”

    Beyond aesthetics, the new Triton Thermal website is fully optimized for search engines, ensuring that data center professionals and IT decision-makers can easily find the company online when searching for liquid cooling solutions. ASTOUNDZ’s expertise as an organic SEO company played a crucial role in this aspect of the project. The website is designed to rank highly on search engines like Google, Bing, and Yahoo, driving more traffic and generating more leads for Triton Thermal’s specialized services.

    “SEO is a critical component of any modern website,” Winter explained. “We made sure that Triton Thermal’s site is not only visually appealing but also performs well in search results, helping them reach more enterprises seeking advanced cooling solutions and grow their liquid cooling business.”

    Another major consideration of the site’s design was mobile responsiveness. With more IT professionals and data center managers researching solutions for urgent cooling challenges via their smartphone or tablet, it was essential that the Triton Thermal site provides a seamless experience across all devices. ASTOUNDZ ensured that the website is fully responsive, meaning it adapts perfectly to any screen size, from desktops to mobile phones.

    “A great user experience is about more than just design,” said Donovan. “It’s about making sure that our clients can access our services wherever they are, on whatever device they’re using. The new website does exactly that, whether someone needs immediate cooling consultation for AI workloads or wants to explore our comprehensive immersion cooling capabilities.”

    As Triton Thermal continues to expand its services and serve new markets in the rapidly growing liquid cooling industry, the new website provides a strong foundation for future growth. The site’s backend is built to support ongoing updates and additions, allowing Triton Thermal to keep its content fresh and relevant. This flexibility ensures that the website will continue to serve the company’s needs as it grows and evolves in the competitive thermal management technology sector.

    About Triton Thermal

    Triton Thermal designs and delivers advanced liquid cooling systems for data centers, AI infrastructure, and high-performance computing. The company engineers precision cooling solutions that address the unique thermal demands of modern computing environments, specializing in direct-to-chip, immersion, and rear-door heat exchange systems. Triton helps clients reduce energy use, cut cooling energy consumption by 30%-50%, unlock higher compute density, and maintain reliable thermal conditions in the most demanding environments. With deep engineering expertise and a focus on custom, end-to-end deployments, Triton empowers enterprises to solve thermal bottlenecks with precision and scale.

    About ASTOUNDZ

    ASTOUNDZ is a Houston-based digital marketing and web development company specializing in creating optimized, high-performance websites that deliver measurable results. With a commitment to excellence and customer satisfaction, ASTOUNDZ offers a full range of digital marketing services, including SEO, web design, social media marketing, and more.

  • Stan Fitzgerald Appointed Acting Press Secretary for Veterans for America First VFAF Georgia State Chapter

    Stan Fitzgerald Appointed Acting Press Secretary for Veterans for America First VFAF Georgia State Chapter

    VFAF Veterans for America First’s Stan Fitzgerald Named Acting Press Secretary for the Georgia State Chapter of the original Veterans for Trump national organization.

    Jul. 14, 2025 / PRZen / ACWORTH, Ga. — From Veterans for America First:

    VFAF’s Georgia State Chapter Political Director Stan Fitzgerald has taken on the role of Acting Press Secretary or the organization.

    Fitzgerald is no stranger to the organizational press as he has published over 500 press releases since 2022 reaching hundreds of millions of impressions.

    Hailing from Caldwell, New Jersey, Stanley Fitzgerald played football in high school and went on to attend Morris County College. At 19 years old Fitzgerald joined the Essex County Sheriff’s department where he rose to the rank of detective. Fitzgerald served in court security, the bureau of narcotics and civil process units. Fitzgerald was awarded numerous accommodations for bravery and exceptional duty. During his time as a narcotics detective, he received training from the NYPD HIDTA unit, NJ State Police, Federal DEA and other agencies. Fitzgerald testified in numerous cases as a court qualified expert in investigative procedures and narcotics enforcement having made hundreds of arrests and been the affiant on dozens of warrants. During his time in the Bureau of Narcotics he was also assigned on loan to the Federal DEA Task Force, Prosecutors Major Case Squad, WESTNET suburbs narcotics enforcement unit, and numerous other details. In 1999 Fitzgerald while suffering from PTSD and having been struck by a drug dealers’ vehicle in an attempt to evade arrest, Fitzgerald retired from law enforcement.

    In 2020 Fitzgerald was asked to serve as Political Director for Veterans for America First who are the original 2015 Veterans for Trump national grassroots. Fitzgerald was later named President of the national group during the Trump Presidential Campaign and is currently director of educational projects. During the campaign he was invited to meet President Trump 13 times between Mar-A-Lago and Bedminster. He served as a Cobb GOP delegate, county chair to David Perdue for governor and on several congressional campaigns. Fitzgerald also officially served on the South Carolina Trump Campaign. Fitzgerald is currently a member of the Paulding County Georgia GOP.

    During his time with Veterans for America First leadership Stan Fitzgerald produced and directed three films relative to Saving America. The first 2023 film earned him a producer’s credit for “The Fall of Deceit” which was geared at exposing and pushing back on wrongful convictions from political persecutions. Fitzgerald took this to heart, having himself lived through it decades ago. The Fall of Deceit premiered in a Georgia movie theatre and was aired on Newsmax. Fitzgerald’s second and third films he took on the role of director. Border Invasion — An American Crisis was filmed on location in Eagle Pass Texas and was geared at promoting a secure border under a forthcoming Trump administration. Border Invasion was a hit, picked up by Salem entertainment and also aired on the CTA Conservative Television of America Network. The film received extensive media coverage on television and radio stations. The film was played in theatres across the country including Texas where congressman elect Brandon Gill was a keynote speaker. In Georgia Team Trump’s congressman elect Brian Jack was a keynote speaker at the screening. Fitzgerald directed his third film “VFAF Veterans for Trump — The Movement” which was geared at motivating the millions of veterans nationwide to get the vote out for President Donald Trump. The film received raving reviews including accolades from Law Enforcement Today. In an unprecedented documentary film making success VFAF Veterans for Trump was also picked up by Salem studios making it three in a row for Fitzgerald to be picked up by a conservative studio.

    To learn more about Veterans for America First visit: Welcome | VETERANS FOR AMERICA FIRST | vfaf.us

    https://youtu.be/htlN-HBdXqE?si=VvQe-FPWbhBqhydx

    Source: Veterans for America First

    Follow the full story here: https://przen.com/pr/33585193

  • A Neurologist and a Mom Join Forces: the Real-World Evidence in the Fight for NurOwn’s Approval for People with ALS

    A Neurologist and a Mom Join Forces: the Real-World Evidence in the Fight for NurOwn’s Approval for People with ALS

    The Real-World Evidence in the Citizens’ Petition Supports the Accelerated Approval of the Stem Cell Therapy that Was Helping People with ALS Live Longer and Breathe Better

    NEW YORK CITY, NY / ACCESS Newswire / July 14, 2025 / Every neurologist who specializes in neuromuscular medicine remembers their first patient… the first time you have to deliver an ALS diagnosis. How do you tell someone that they will lose the ability to walk, talk, move, eat, drink, swallow, and eventually, breathe? There is no easy way to tell someone that ALS is always fatal and there are no disease-modifying treatments.

    In every physician’s heart there is that first patient that you always remember. And then another patient comes along and imprints on your soul. For me, after 15 years of practice, that patient was Kade Simons. I share his story jointly and with the permission of his mother.

    Kade Simons died of ALS on August 4, 2024 – just a week before his 27th birthday. His passing was the most devastating in all my years as a neurologist. Some patients just settle in your heart, make a home there and never leave. Kade did that.

    Kade, his mom Kandy and I met at our first telehealth appointment in December of 2022. Right away, Kade made it clear that he didn’t care much for doctors. But somehow we clicked. He saw I was wearing black nail polish and this resonated with him, so he took a liking to me. At the next appointment, my nails were no longer black. With his mischievous grin and his twinkling blue eyes, he gave me a little side-eye. It made me think about those small things in life that we, as humans, find connection in. In hindsight, I realize just why he liked my nail polish and it crushes my soul. Why? Because he was a mere 6 years older than my own daughter. SIX YEARS. He looked at me the way my own children look at me when maybe I am a little on trend and they find me relatable. And now I realize why Kade took a special place in my spirit; because he was a child and this tore at my maternal core.

    No mother should ever have to bury a child. I wish that everyone on the NurOwn Advisory Committee two years ago would have been forced to look into the eyes of a vibrant 20-something year-old and reconcile that they ignored his compelling testimony. That is the testimony Kade and Kandy shared with me.

    Kade’s Experience with NurOwn
    At that first appointment, I sat in amazement as Kandy and Kade shared the story about Kade’s participation in the NurOwn stem cell trial at Mayo. Kade received 3 doses of NurOwn from July to November of 2019. Although the trial had not yet been unblinded, Kade and his mom were adamant that he was in the treatment arm.

    Kade felt NurOwn work almost immediately. He told me that his fasciculations stopped. They showed me videos. After his first dose, he felt his foot “popping up” when he walked. Translation: his foot drop was improving as his brain’s messages were getting delivered again to his foot muscles. Kandy then narrated a video where Kade exclaimed that he was having to get used to the renewed strength in his legs that he hadn’t experienced in a while. With every dose of NurOwn, Kade felt stronger, walked easier, had more range of motion, less spasticity, clonus and cramping. His physical therapist agreed.

    The more we talked, the more I became intrigued. Kade had ALS onset in three regions: bulbar and both upper and lower limbs. Consistent with his multi-loci onset and ALS natural history, Kade was initially a fast progressor. But his medical records showed that his lethal progression abruptly slowed after he started receiving NurOwn.

    And so important and “clinically meaningful” to any 24-year-old, Kade was still able to use his hands to text and to play video games with his brother and friends – maintaining that social connection with his peers. In my professional experience, all of this was extremely unusual for someone four years post-diagnosis.

    Kade boasted that he was still able to eat pizza and Jersey Mike’s subs – something that both the neurologist and the Italian girl in me appreciated. Eating without limitations four years after diagnosis is highly unusual in ALS. But it’s almost unheard of in someone who began their ALS journey with bulbar onset.

    But most of all, I was astounded that Kade was still breathing on his own without the assistance of non-invasive ventilation. He was sleeping laying flat (something that doesn’t happen when the nerves innervating your diaphragm muscles start to die). Kade’s pulmonologist agreed about the rarity of Kade’s normal respiratory function.

    Kade had been a college baseball player. As an athlete, Kade made quite clear to me that he knew his body. He knew when it worked and he knew when it didn’t. He was insulted that people would doubt when he said NurOwn improved how he functioned. Kandy too said, “I watched Kade improve on NurOwn.” Just as Kade knew his body, a mom knows her child.

    Kade asked me if I believed them. I did.

    In the months after that first appointment with Kade, I had the chance to meet with several other patients in the NurOwn trial. Many of these patients reported similar improvements and their medical records mirrored those experiences. The more patients I met, the more records I reviewed, the more I believed in NurOwn’s efficacy. The people who thought they were in the placebo arm (or were non-responders) had medical records that reflected their decline; but those who were as adamant as Kade that they were in the NurOwn arm had medical records that reflected a stark contrast.

    My Expert Opinion as a Neuromuscular Specialist with Documented RWE
    I promised Kade – in life – that I would try my best to advocate for him and all others brutalized by this disease.

    When it came time for the NurOwn Advisory Committee meeting in 2023, I was compelled to share, not just my clinical observations outside the trial (evidence the FDA calls “real-world evidence”), but also my expert opinion as a neuromuscular specialist who has treated well over a thousand people with ALS. Because of my tele-neurology practice, I suspected I had seen more NurOwn recipients than any other neurologists besides the trials’ investigators. And uniquely, I saw them years after the 28-week trial ended. Thus, my observations could provide clinical evidence about the durability of my patients’ responses on NurOwn.

    I submitted a Public Comment to the FDA sharing my professional opinion that NurOwn worked on some people.

    “I have been working in the ALS clinical space and in ALS multidisciplinary clinics for over 15 years….
    I have seen the full breadth of clinical constellations playing out over time. What I have not seen, though,
    is anyone with significant functional improvement from a declining baseline;
    I have not seen patients rise from plateaus. It does not happen in the natural course of ALS.
    It did happen with the introduction of NurOwn.
    The real-world evidence could not be more striking.
    I have known patients nearly immobile who gained some functionality in their gait,
    patients with severe dysarthria become intelligible, patients who could not manage the fine motor skill
    needed to button or zipper, finally able to dress independently.”

    I implored the FDA to consider the risk of a Type II error – failing to approve a drug that does work.

    “I implore you to open your minds and to take my clinical observations and this real world evidence
    just as you would any solid data set from a trial. Consider this evidence as if it were your patient
    you observed in your own clinic…. Not all evidence manifests in the confines of a trial.
    Listen to the narratives of these patients and their physicians. NurOwn works.
    The science of the trial, the art of our clinical observations and attention to our patients’ accounts
    demonstrates the truth of this statement.… Please allow this treatment to come to market
    with a phase 4 post-marketing trial. Let other neurologists witness what I have seen in my own patients.
    Let thousands more patients have a chance to benefit from NurOwn.”

    I knew death would be imminent for so many of my patients if they couldn’t get more NurOwn. They had already defied the odds. I knew the ALS clock wouldn’t wait five more years for another Phase 3 trial. Kade had already lived nearly four years past his last dose of NurOwn in 2019.

    The Citizens’ Petition
    Kade was strong, determined, and courageous, and so too is his mother Kandy-who, despite her grief over the loss of her son, is a Petitioner in the recent Citizens’ Petition. This 309-page legal document seeks accelerated approval of NurOwn based on powerful survival and respiratory data, along with real-world evidence from the now-unblinded trial participants.

    The Citizens’ Petition relies upon the promise of the 21st Century Cures Act, wherein Congress encouraged the FDA to use real-world evidence and patient experiences – data from actual patients like Kade and the EAP participants. In 100% terminal and heterogeneous rare diseases, every story matters and every type of evidence matters.

    When the trial was unblinded after the Advisory Committee meeting, I was not surprised to learn that – almost without exception – every one of my patients accurately predicted if they received NurOwn or placebo. As the Citizens’ Petition states:

    “When people are dying, they know when a drug helps them live.
    When people are becoming paralyzed, they know when a drug helps them move again.
    And when people can’t breathe without a non-invasive ventilator,
    they know when a drug helps them breathe again.”

    The new data in the Citizens’ Petition illustrates that the FDA’s focus on the primary endpoint alone overlooked the totality of the evidence, and I believe resulted in a Type II statistical error. The totality of the evidence included: the data of responders earlier in progression, objective biomarker data, compelling patient experiences, neurologists’ observations, and expert opinions, like those detailed in the 309-page Citizens’ Petition. For example, the FDA failed to heed the opinions of esteemed ALS clinical trialists with four decades of experience like Dr. Robert Brown of UMass Chan School of Medicine and Dr. Anthony Windebank of Mayo Clinic. They opined that a “significant number” of people had a “clinically meaningful” response to NurOwn, that it caused progression-free survival in some, and even helped some regain function – just as Kade told me.

    Although Kade was not chosen to receive additional doses in the Expanded Access Program (EAP), his data too is informative and it was included in the Citizens’ Petition. I can corroborate Kade’s submitted data:

    Kade had symptom onset in three regions concurrently. Kade was a fast progressor, losing 1 point per month
    before receiving NurOwn. Kade’s first bulbar symptoms occurred in May of 2018…. By the time Kade received
    NurOwn in July of 2019, his ALSFRS-R score had plummeted to 34…. NurOwn caused the most durable impact
    on Kade’s respiratory and bulbar function…. Kade didn’t get a feeding tube until February of 2024, and even then
    he still continued to eat things like pizza and Jersey Mike’s Subs up until a few months before his death in
    August of 2024. Most impressively, Kade did not use NIV up until the time of his death.

    In addition to the long-term data from people in the Phase 3 trial and EAP, the Citizens’ Petition also submitted the following unprecedented survival and respiratory data:

    • 100% five-year survival in EAP vs. 20% natural history
      (p-value = ~0.000335 (one-sided) or ~0.000671 (two-sided)

    • EAP Median ≈ 7 year Tracheostomy-free survival (60-103 month range) vs. 30 month median in ALS natural history

    • Progression-free survival (range up to 17 months)

    • Long-term slowing of ALS progression of up to 85%

    • Halting of respiratory decline

    • Range of 5-8+ years in time-to-NIV vs. 15-27 months natural history

    Notably, comparing the above survival data to exhibit A & B in the Petition, the NurOwn survival data meets or beats the survival data supporting the accelerated approval of dozens of cancer therapies.

    The Citizens’ Petition also cites multiple studies that conclude that almost no one with multi-loci ALS onset survives five years. But Kade did.

    Kade beat the bulbar onset natural history data as well. On pages 29-32, the Petition reports that the median lifespan for people with bulbar onset is approximately 2 years from symptom onset and 1.5 years from diagnosis. This is consistent with my professional experience. The Petition reports that NurOwn recipients who had bulbar onset lived approximately 3.5 years longer than the median in ALS natural history.

    Applying these above peer-reviewed criteria to Kade, I can confirm, as Kade’s treating neurologist, that:

    • Kade Lived “trach-free” 78 months (6.5 years) from symptom onset vs. the 2-year average for bulbar onset

    • Kade’s progression slowed from more than 1 point per month on the ALSFRS-R down to 0.16 points per month

    • Kade chose not to use a bi-pap to breathe and thus at the time of his death (68 months from diagnosis), Kade’s time-to-NIV dwarfed the ALS natural history of 15 months for fast progressors and the 13.5 months for people with bulbar onset.

    As Kade’s treating neurologist, these data align with the Public Comment that I submitted in 2023. They also align with Kandy’s Public Comment and testimony that she shared at the NurOwn Advisory Committee meeting. These data in the Citizens’ Petition further strengthen my expert opinion and resolve that NurOwn helped Kade breathe better and live longer.

    It is a tragedy unlike anything I have experienced in my career that Kade was denied continued access to the stem cell therapy that was helping him live.

    Gold Standard Science and Common Sense Support Approval
    I am heartened to read that Commissioner Makary is committed to marry gold standard science and common sense.

    As such, I implore the FDA to consider the new and unprecedented survival and respiratory data that is reasonably likely to predict a clinically meaningful impact. Listen to the opinions of the neurologists who treated the patients. But most of all, listen to the patients. They are the only ones who know what it feels like to die a little more each day. And the new data proves that they were right. They knew when NurOwn helped them live.

    Thus, substantial evidence supports the approval of NurOwn. Please approve NurOwn with a Phase 4 post-marketing study. Please show my patients with ALS the same compassion and humanity that the Oncology Center of Excellence shows cancer patients.

    My Promise to Kade
    Today, with this Press Release, I renew my promise to Kade. As I did during his life, I will continue to do after his death. For whatever number of years God blesses me to continue helping people with ALS, I will move forward with the same resolve that Kade and his family have shown.

    Please hold space in your heart today for the 26-year-old man with the resolve and courage that I could never fathom possessing.
    God rest him.

    About Danielle Geraldi-Samara, MD
    For over 15 years, Dr. Geraldi-Samara has diagnosed and treated people with ALS. She attended medical school at the State University of New York at Syracuse and completed her residency and neuromuscular fellowship at the Mount Sinai School of Medicine. With the goal of bringing ALS care closer for local patients, Dr. Geraldi-Samara helped establish an ALS/Neuromuscular clinic from the ground up at NYU-Brooklyn. She also served as a supervising Neuromuscular Specialist at Northwell Health’s multidisciplinary ALS clinic in New York.

    Dr. Geraldi-Samara counts patient relationships as the driving force in her career. Because of the inequity in ALS regulatory policy and law – and Kade’s inability to get more of the drug that was helping him live – Dr. Geraldi has resumed her academic career, where she is currently working on a master’s degree in bioethics. While continuing her neuromuscular practice, she also wants to work to transform regulatory policy for patients with terminal rare diseases like ALS.

    About Kandy Simons
    Kandy Simons is the mother of Kade Simons. She has become a patient advocate to right the wrongs that were inflicted upon her son and her family. She lives in Oklahoma City, Oklahoma with her husband Mitchel Simons as well as her only remaining child, Kruz Simons.

    About NurOwn
    Developed by Brainstorm Cell Therapeutics, NurOwn is a mesenchymal stem cell therapy marries the restorative powers of stem cells with the regenerative powers of neurotrophic factors. NurOwn is made from your body’s own stem cells harvested from a bone marrow aspiration. They are then treated in a lab and supercharged to release neurotrophic factors. Once injected directly into the CSF, your stem cells work like a Fed Ex truck, delivering nano-packages of neurotrophic factors and immunomodulatory cytokines directly to the sites of the motor neurons damaged by ALS. The neurotrophic factors act like “Miracle-Gro” for your neurons.

    Contact :

    1. Danielle Geraldi-Samara, MD
      (mail to: DGSneuro@gmail.com)

    2. Nicholas Warack, Esq.
      (mail to: Veterans4NurOwn@gmail.com)

    3. Mitze Klingenberg, BSN RN
      (mail to: NurOwnWorks@gmail.com)

    Copy of Citizens’ Petition and Exhibits Filed with the FDA:
    Join Dr. Geraldi, Kandy Simons and many others in urging the FDA to approve NurOwn for people with ALS. The 309-page Citizens’ Petition includes the data supporting approval as well as easy-to-read charts and graphs that show how NurOwn extended lifespan and improved function for people with ALS. You can see the data and graphics, as well as Petitioners’ stories at: https://www.nurownworks.com/

    SOURCE: NurOwn Citizen’s Petition

    View the original press release on ACCESS Newswire